Metabolic sensing, "biochemical evolution" and cell fate
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"Do. Or do not. There is no try." - Yoda
"Around here we don't look backwards for very long. We keep moving forward, opening up new doors and doing new things, because we're curious......and curiosity keeps leading us down new paths." - Walt Disney
Welcome to the Sunil Laxman lab website at the Institute for Stem Cell Biology and Regenerative Medicine (inStem), located within the National Center for Biological Sciences (NCBS) campus.
Our research is entirely driven by curiosity, and the desire to make discoveries. We are broadly interested in information transfer within and between cells, with a focus on metabolic information. Our goal is to understand what makes some metabolites or metabolic processes special, and how cells can sense and respond to different metabolic states, to attain different fates. We are especially interested in the many unique things amino acids do in a cell. In this context, our research extends to understanding: the different fates of amino acids, interconnections between metabolism and protein translation, mechanisms of inter-organellar signaling, what "metabolic costs" actually mean to a cell, and finally taking a metabolism centric perspective to answer how cellular heterogeniety can emerge in isogenic populations.
You can learn more about our work on our research page, read our publications, join us, and explore our resources.
Our research is supported by a Wellcome Trust-DBT India Alliance fellowship, grants and institutional support from inStem and DBT ( Centre of Excellence grant), and infrastructure support from inStem, NCBS and C-CAMP.
Other: I write an occasional science column for The Wire (which does not reflect the views of my employer), on the scientific method, learning from the history of science, and the process of discovery. In addition, here are some of my other articles in the mainstream media:
1) On Scaling Indian science
2) On Effectively starting up a new lab (in the Wellcome Trust -DBT IA newsletter)
3) "Who moved my science", a science policy discussion on the Pragati podcast
email (strongly preferred): email@example.com
office phone: +91-80-23666580
Snail mail/physical address:
Institute for Stem Cell Biology and Regenerative Medicine (inStem)
National Center for Biological Sciences campus,
GKVK, Bellary Road,
Bangalore 560065 India
Institute (official/other) website: