SL profiles: NCBI bibliography / Pubmed / Google Scholar / ResearchGate / ORCID
Publications from our lab at inStem (2015-present):
Preprints (biorxiv) under review:
1. Gupta R, Adhikary S, Dalpatraj N, Laxman S*. A demand-based framework explains prioritization strategies upon transient limitations of different amino acids
bioRxiv 2023.07.31.551408; doi: https://doi.org/10.1101/2023.07.31.551408
2. Vengayil V, Niphadkar S, Adhikary S, Varahan S, Laxman S*. Phosphate budgeting to mitochondria controls glucose-mediated mitochondrial repression
Biorxiv: https://www.biorxiv.org/content/10.1101/2022.12.29.522272v2
Peer reviewed publications:
2024
50. Niphadkar S, Karinje L, Laxman S*. The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion. Plos Genetics 20(3): e1011202.
Free full text
Original Biorxiv preprint
2023
49. Das M, Sreedharan S, Shee S, Malhotra N, Nandy M, Banerjee U, Kohli S, Rajmani RS, Chandra N, Seshasayee ASN, Laxman S, Singh A*. Cysteine desulfurase (IscS)-mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence. Science Advances. 2023 Dec 15;9(50):eadh2858. doi: 10.1126/sciadv.adh2858. Epub 2023 Dec 13.
48. Prasad A, Sreedharan S, Bakthavachalu B*, Laxman S*. Eggs of the mosquoto Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism. Plos Biology 21(10): e3002342.
Free full text | Global media coverage
Original Biorxiv preprint
47. Shee S, Veetil RT, Mohanraj K, Das M, Malhotra N, Bandopadhyay D, Beig H, Birua S, Niphadkar S, Nagarajan SN, Sinha VK, Thakur C, Rajmani RS, Chandra N, Laxman S, Singh M, Samal A, Seshasayee AN, Singh A. Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis. Elife. 2023 Aug 29;12:e80218.
Full text
46. Singh G, George G, Raja SO, Kandaswamy P, Kumar M, Thutupalli S, Laxman S, Gulyani A* (2023). A molecular rotor FLIM probe reveals dynamic coupling between mitochondrial inner membrane fluidity and cellular respiration. P.N.A.S. 120 (24) e2213241120
Full text
2022
45. Naaz A#, Saini N#, Metur S#, Gahlot P#, Walvekar A, Dutta A, Davathamizhan U, Sarin S*, Laxman S* (2022). Methionine uptake via SLC43A2 transporter is essential for regulatory T lymphocyte survival. Life Science Alliance Sep 2022, 5 (12) e202201663; DOI: 10.26508/lsa.202201663
Full text and link
Original BioRXIV preprint
44. Bandyopadhyay P, Pramanick I, Biswas R, Ps S, Sreedharan S, Singh S, Rajmani RS, Laxman S, Dutta S, Singh A. (2022). S-Adenosylmethionine-responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis. Science Advances. 2022 Jun 24;8(25):eabo0097. doi: 10.1126/sciadv.abo0097. Epub 2022 Jun 24.
Full text & pdf
43. Tripathi A, Anand K, Das M, O'Niel RA, P S S, Thakur C, R L RR, Rajmani RS, Chandra N, Laxman S, Singh A. (2022). Mycobacterium tuberculosis requires SufT for Fe-S cluster maturation, metabolism, and survival in vivo. PLoS Pathog. 2022 Apr 15;18(4):e1010475. doi: 10.1371/journal.ppat.1010475.
Full text & pdf
2021
42. Rashida Z* and Laxman S* (2021). The pentose phosphate pathway and organization of metabolic networks enabling growth programs. Current Opinions in Systems Biology https://doi.org/10.1016/j.coisb.2021.100390
Full text | pdf download
42. Varahan S* and Laxman S* (2021). Bend or break: how biochemically versatile molecules enable metabolic division of labor in clonal microbial communities. Genetics Volume 219, Issue 2, October 2021, iyab109. https://doi.org/10.1093/genetics/iyab109
Full text (free)
41. Rashida S, Srinivasan R, Cyanam M and Laxman S* (2021). Kog1/Raptor mediates metabolic rewiring during nutrient limitation by controling SNF1/AMPK activity. Science Advances 14 Apr 7(16) eabe5554.
Full text (free)
40. Laxman S* (2021). The bacterial social network and beyond (journal club). Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-021-00369-3
Full text | pdf download
39. Gupta R and Laxman S* (2021). Cycles, sources and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks
eLife 2021;10:e63341
Full text (free)
2020
38. Srinivasan R, Walvekar A, Seshasayee ASN*, Laxman S* (2020). Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program.
Plos Genetics. 16(12): e1009252
Full text (free)
original Biorxiv preprint
37. Walvekar A, Kadamur G, Sreedharan S, Gupta R, Srinivasan R and Laxman S* (2020). Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program.
J. Biol. Chem. 295(52) 18390–18405 doi: 10.1074/jbc.RA120.014248 (early online Oct 29th 2020)
Full text (free)
original Biorxiv preprint
36. Varahan S, Sinha V, Walvekar A, Krishna S and Laxman S* (2020). Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community.
eLIFE 2020;9:e57609 doi: 10.7554/eLife.57609
Full text (free)
Original Biorxiv preprint
Clarification/correction
Coverage:
inStem news | India Alliance site
35. Bhatia M, Thakur J, Suyal S, Oniel R, Chakraborty R, Pradhan S, Sharma M, Sengupta S, Laxman S, Masakapalli SK, Bachhawat AK. (2020) Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one carbon metabolism.
J. Biol. Chem. 2020 Sep 15:jbc.RA120.015129. doi: 10.1074/jbc.RA120.015129.
Full text (free)
(f
34. Bruhn C, Ajazi A, Ferrari E, Lanz MC, Batrin R, Choudhary R, Walvekar A, Laxman S, Longhese MP, Fabre E, Smolka MB, Foiani M. (2020). The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing.
Nat Commun. 11(1):4154. doi: 10.1038/s41467-020-17961-4.
Full text (free)
33. (Book chapter) Krishna S and Laxman S. Emergence of metabolic heterogeneity in cell populations: lessons from budding yeast. Chapter in "Phenotypic Switching: Implications in Biology and Medicine" (First edition, 2020). Link
32. Negi H, Reddy PP, Vengayil V, Patole C, Laxman S, Das R (2020). A novel polyubiquitin chain linkage formed by viral Ubiquitin is resistant to host deubiquitinating enzymes.
Biochem J. 2020 Jun 26;477(12):2193-2219. doi: 10.1042/BCJ20200289.
Pubmed link
31. Gupta R and Laxman S* (2020). Steady-state and Flux-based Trehalose Estimations as an Indicator of Carbon Flow from Gluconeogenesis or Glycolysis.
Bio-protocol 10(1): e3483
Full text (free)
(related to methods used in Gupta R et al, eLIFE 2019 and Varahan S et al, eLIFE 2020)
2019
30. Gupta R and Laxman S* (2019). tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state.
Current Genetics doi: 10.1007/s00294-019-01045-y
Full text
29. Walvekar A and Laxman S* (2019). Methionine at the Heart of Anabolism and Signaling: Perspectives From Budding Yeast.
Frontiers in Microbiol. 10:2624 doi: 10.3389/fmicb.2019.02624
Full text (Free)
28. Shaw E, Talwadekar M, Rashida Z, Mohan N, Acharya A, Khatri S, Laxman S, Kolthur-Seetharam U (2019). Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria.
Mol. Cell. Biol. doi: 10.1128/MCB.00212-19
Full text and PDF link
27. Vengayil V, Rashida Z and Laxman S* (2019). The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability.
J. Biol. Chem. 294, 17209-17223.
Full text (free)
Original bioRxiv preprint
26. Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S* (2018). A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis, to couple metabolism to cell cycle progression.
eLIFE 2019; 8:e44795
Full text (free)
Original bioRxiv preprint
Coverage
eLife Digest | India Alliance site | NCBS & inStem news
25. Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S* (2019). Metabolic constraints drive self-organization of cell groups.
eLIFE 2019; 8:e46735
Full text (free)
Original bioRxiv preprint
Clarification/correction
Coverage:
eLIFE digest | India Alliance site | inStem & NCBS news
Popular press coverage: The Hindu (Sunday Sept 7th, 2019)
F1000 prime rated (exceptional)
2018
24. Walvekar A, Srinivasan R, Gupta R and Laxman S* (2018). Methionine coordinates a hierarchically organized anabolic program.
Molecular Biology of the Cell. 2018, 29(26):3183-3200
PDF link (free)
Coverage:
Selected as "A Highlights from MBoC Selection"
News article on the inStem site | Article on the Wellcome Trust- India Alliance website
Other: Eureka alert | Phys.org | News Medical/Lifesciences | MedIndia | Science Daily
Original BioRXIV preprint
23. Walvekar A*, Rashida Z, Maddali H and Laxman S* (2018). A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways. Wellcome Open Res 2018, 3:122
Full text (free)
22. Krishna S* and Laxman S*. (2018) A minimal "push-pull" bistability model explains oscillations between quiescent and proliferative cell states.
Molecular Biology of the Cell. 2018, 29(19):2243-2258
Full text (free)
Coverage:
Highlighted on PreLights | News article on the NCBS and inStem news site | Article on the Wellcome-DBT India Alliance site
Selected as "A Highlights from MBoC Selection"
Featured in the ASCB Newsletter (Dec 2018)
2017
21. RVR Choudhury, A Prabhakar, Laxman S (2017) Optofluidic platform to investigate cell community behavior in microenvironments,
Life Sciences Conference (LSC), 2017 IEEE, 51-54
PDF link
20. Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload,
Deshpande AA, Bhatia M, Laxman S*, Bachhawat AK*. Microbial Cell, 2017, Vol. 4, No. 4, pp. 112 - 126.
Full text (free)
19. Conceptualizing Eukaryotic Metabolic Sensing and Signaling.
Laxman S*. J Indian Institute of Science, 2017, 97(1):59-77
Full text (free)
2016
18. The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast.
Erkut C, Gade VR, Laxman S, Kurzchalia TV. eLIFE 2016 Apr 19;5. pii: e13614.
Full text (free)
Coverage: MPI-CBG news | inStem news
Covered by several mainstream newspapers
F1000 Prime Recommended
2015
17. Decoding the stem cell quiescence cycle--lessons from yeast for regenerative biology.
Dhawan J, Laxman S.* J. Cell Science. 2015; 128(24):4467-74.
Full text (free)
Publications from post-doctoral work (SL):
(2007-2014)
16. Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.
Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K.
J. Biol. Chem. 2016; 291(20):10515-27.
PDF link / Pubmed link
15. Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.
Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP. Cell Reports. 2015; 12(3):371-9.
PDF link / Pubmed link
14. Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites.
Laxman S, Sutter BM, Shi L, Tu BP. Science Signaling. 2014; 7(356):ra120.
PDF link / Pubmed link
13. Concerted effort: oscillations in global gene expression during nematode development.
Laxman S, Tu BP, McKnight SL. Mol. Cell. 2014; 53(3):363-4.
Pubmed link
12. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A.
Laxman S, Sutter BM, Tu BP. Autophagy. 2014; 10(2):386-7.
PDF link / Pubmed link
11. Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A.
Sutter BM, Wu X, Laxman S, Tu BP. Cell. 2013; 154(2):403-15.
PDF link / Pubmed link
10. Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation.
Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP. Cell. 2013; 154(2):416-29.
PDF link / Pubmed link
9. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT. PNAS. 2013; 110(24):9728-33.
Pubmed link
8. Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae.
Laxman S, Tu BP. PloS One. 2011; 6(10):e26081.
PDF link / Pubmed link
7. Systems approaches for the study of metabolic cycles in yeast.
Laxman S, Tu BP. Curr. Op. in Genetics & Development. 2010; 20(6):599-604.
PDF link / Pubmed link
6. Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters.
Laxman S, Sutter BM, Tu BP. PloS One. 2010; 5(9):e12595.
PDF link / Pubmed link
Publications from doctoral work (SL):
(2001-2006)
5. Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents.
Laxman S, Beavo JA. Molecular Interventions. 2007; 7(4):203-15.
4. Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.
Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA. PNAS. 2006; 103(50):19194-9.
3. Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi.
Díaz-Benjumea R*, Laxman S*, Hinds TR, Beavo JA, Rascón A. Biochem. Journal. 2006; 399(2):305-14.
2. Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.
Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T. Molecular and Biochemical Parasitology. 2006; 145(1):133-5.
1. Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain.
Laxman S, Rascón A, Beavo JA. J. Biol. Chem. 2005; 280(5):3771-9.
Publications from our lab at inStem (2015-present):
Preprints (biorxiv) under review:
1. Gupta R, Adhikary S, Dalpatraj N, Laxman S*. A demand-based framework explains prioritization strategies upon transient limitations of different amino acids
bioRxiv 2023.07.31.551408; doi: https://doi.org/10.1101/2023.07.31.551408
2. Vengayil V, Niphadkar S, Adhikary S, Varahan S, Laxman S*. Phosphate budgeting to mitochondria controls glucose-mediated mitochondrial repression
Biorxiv: https://www.biorxiv.org/content/10.1101/2022.12.29.522272v2
Peer reviewed publications:
2024
50. Niphadkar S, Karinje L, Laxman S*. The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion. Plos Genetics 20(3): e1011202.
Free full text
Original Biorxiv preprint
2023
49. Das M, Sreedharan S, Shee S, Malhotra N, Nandy M, Banerjee U, Kohli S, Rajmani RS, Chandra N, Seshasayee ASN, Laxman S, Singh A*. Cysteine desulfurase (IscS)-mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence. Science Advances. 2023 Dec 15;9(50):eadh2858. doi: 10.1126/sciadv.adh2858. Epub 2023 Dec 13.
48. Prasad A, Sreedharan S, Bakthavachalu B*, Laxman S*. Eggs of the mosquoto Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism. Plos Biology 21(10): e3002342.
Free full text | Global media coverage
Original Biorxiv preprint
47. Shee S, Veetil RT, Mohanraj K, Das M, Malhotra N, Bandopadhyay D, Beig H, Birua S, Niphadkar S, Nagarajan SN, Sinha VK, Thakur C, Rajmani RS, Chandra N, Laxman S, Singh M, Samal A, Seshasayee AN, Singh A. Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis. Elife. 2023 Aug 29;12:e80218.
Full text
46. Singh G, George G, Raja SO, Kandaswamy P, Kumar M, Thutupalli S, Laxman S, Gulyani A* (2023). A molecular rotor FLIM probe reveals dynamic coupling between mitochondrial inner membrane fluidity and cellular respiration. P.N.A.S. 120 (24) e2213241120
Full text
2022
45. Naaz A#, Saini N#, Metur S#, Gahlot P#, Walvekar A, Dutta A, Davathamizhan U, Sarin S*, Laxman S* (2022). Methionine uptake via SLC43A2 transporter is essential for regulatory T lymphocyte survival. Life Science Alliance Sep 2022, 5 (12) e202201663; DOI: 10.26508/lsa.202201663
Full text and link
Original BioRXIV preprint
44. Bandyopadhyay P, Pramanick I, Biswas R, Ps S, Sreedharan S, Singh S, Rajmani RS, Laxman S, Dutta S, Singh A. (2022). S-Adenosylmethionine-responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis. Science Advances. 2022 Jun 24;8(25):eabo0097. doi: 10.1126/sciadv.abo0097. Epub 2022 Jun 24.
Full text & pdf
43. Tripathi A, Anand K, Das M, O'Niel RA, P S S, Thakur C, R L RR, Rajmani RS, Chandra N, Laxman S, Singh A. (2022). Mycobacterium tuberculosis requires SufT for Fe-S cluster maturation, metabolism, and survival in vivo. PLoS Pathog. 2022 Apr 15;18(4):e1010475. doi: 10.1371/journal.ppat.1010475.
Full text & pdf
2021
42. Rashida Z* and Laxman S* (2021). The pentose phosphate pathway and organization of metabolic networks enabling growth programs. Current Opinions in Systems Biology https://doi.org/10.1016/j.coisb.2021.100390
Full text | pdf download
42. Varahan S* and Laxman S* (2021). Bend or break: how biochemically versatile molecules enable metabolic division of labor in clonal microbial communities. Genetics Volume 219, Issue 2, October 2021, iyab109. https://doi.org/10.1093/genetics/iyab109
Full text (free)
41. Rashida S, Srinivasan R, Cyanam M and Laxman S* (2021). Kog1/Raptor mediates metabolic rewiring during nutrient limitation by controling SNF1/AMPK activity. Science Advances 14 Apr 7(16) eabe5554.
Full text (free)
40. Laxman S* (2021). The bacterial social network and beyond (journal club). Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-021-00369-3
Full text | pdf download
39. Gupta R and Laxman S* (2021). Cycles, sources and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks
eLife 2021;10:e63341
Full text (free)
2020
38. Srinivasan R, Walvekar A, Seshasayee ASN*, Laxman S* (2020). Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program.
Plos Genetics. 16(12): e1009252
Full text (free)
original Biorxiv preprint
37. Walvekar A, Kadamur G, Sreedharan S, Gupta R, Srinivasan R and Laxman S* (2020). Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program.
J. Biol. Chem. 295(52) 18390–18405 doi: 10.1074/jbc.RA120.014248 (early online Oct 29th 2020)
Full text (free)
original Biorxiv preprint
36. Varahan S, Sinha V, Walvekar A, Krishna S and Laxman S* (2020). Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community.
eLIFE 2020;9:e57609 doi: 10.7554/eLife.57609
Full text (free)
Original Biorxiv preprint
Clarification/correction
Coverage:
inStem news | India Alliance site
35. Bhatia M, Thakur J, Suyal S, Oniel R, Chakraborty R, Pradhan S, Sharma M, Sengupta S, Laxman S, Masakapalli SK, Bachhawat AK. (2020) Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one carbon metabolism.
J. Biol. Chem. 2020 Sep 15:jbc.RA120.015129. doi: 10.1074/jbc.RA120.015129.
Full text (free)
(f
34. Bruhn C, Ajazi A, Ferrari E, Lanz MC, Batrin R, Choudhary R, Walvekar A, Laxman S, Longhese MP, Fabre E, Smolka MB, Foiani M. (2020). The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing.
Nat Commun. 11(1):4154. doi: 10.1038/s41467-020-17961-4.
Full text (free)
33. (Book chapter) Krishna S and Laxman S. Emergence of metabolic heterogeneity in cell populations: lessons from budding yeast. Chapter in "Phenotypic Switching: Implications in Biology and Medicine" (First edition, 2020). Link
32. Negi H, Reddy PP, Vengayil V, Patole C, Laxman S, Das R (2020). A novel polyubiquitin chain linkage formed by viral Ubiquitin is resistant to host deubiquitinating enzymes.
Biochem J. 2020 Jun 26;477(12):2193-2219. doi: 10.1042/BCJ20200289.
Pubmed link
31. Gupta R and Laxman S* (2020). Steady-state and Flux-based Trehalose Estimations as an Indicator of Carbon Flow from Gluconeogenesis or Glycolysis.
Bio-protocol 10(1): e3483
Full text (free)
(related to methods used in Gupta R et al, eLIFE 2019 and Varahan S et al, eLIFE 2020)
2019
30. Gupta R and Laxman S* (2019). tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state.
Current Genetics doi: 10.1007/s00294-019-01045-y
Full text
29. Walvekar A and Laxman S* (2019). Methionine at the Heart of Anabolism and Signaling: Perspectives From Budding Yeast.
Frontiers in Microbiol. 10:2624 doi: 10.3389/fmicb.2019.02624
Full text (Free)
28. Shaw E, Talwadekar M, Rashida Z, Mohan N, Acharya A, Khatri S, Laxman S, Kolthur-Seetharam U (2019). Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria.
Mol. Cell. Biol. doi: 10.1128/MCB.00212-19
Full text and PDF link
27. Vengayil V, Rashida Z and Laxman S* (2019). The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability.
J. Biol. Chem. 294, 17209-17223.
Full text (free)
Original bioRxiv preprint
26. Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S* (2018). A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis, to couple metabolism to cell cycle progression.
eLIFE 2019; 8:e44795
Full text (free)
Original bioRxiv preprint
Coverage
eLife Digest | India Alliance site | NCBS & inStem news
25. Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S* (2019). Metabolic constraints drive self-organization of cell groups.
eLIFE 2019; 8:e46735
Full text (free)
Original bioRxiv preprint
Clarification/correction
Coverage:
eLIFE digest | India Alliance site | inStem & NCBS news
Popular press coverage: The Hindu (Sunday Sept 7th, 2019)
F1000 prime rated (exceptional)
2018
24. Walvekar A, Srinivasan R, Gupta R and Laxman S* (2018). Methionine coordinates a hierarchically organized anabolic program.
Molecular Biology of the Cell. 2018, 29(26):3183-3200
PDF link (free)
Coverage:
Selected as "A Highlights from MBoC Selection"
News article on the inStem site | Article on the Wellcome Trust- India Alliance website
Other: Eureka alert | Phys.org | News Medical/Lifesciences | MedIndia | Science Daily
Original BioRXIV preprint
23. Walvekar A*, Rashida Z, Maddali H and Laxman S* (2018). A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways. Wellcome Open Res 2018, 3:122
Full text (free)
22. Krishna S* and Laxman S*. (2018) A minimal "push-pull" bistability model explains oscillations between quiescent and proliferative cell states.
Molecular Biology of the Cell. 2018, 29(19):2243-2258
Full text (free)
Coverage:
Highlighted on PreLights | News article on the NCBS and inStem news site | Article on the Wellcome-DBT India Alliance site
Selected as "A Highlights from MBoC Selection"
Featured in the ASCB Newsletter (Dec 2018)
2017
21. RVR Choudhury, A Prabhakar, Laxman S (2017) Optofluidic platform to investigate cell community behavior in microenvironments,
Life Sciences Conference (LSC), 2017 IEEE, 51-54
PDF link
20. Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload,
Deshpande AA, Bhatia M, Laxman S*, Bachhawat AK*. Microbial Cell, 2017, Vol. 4, No. 4, pp. 112 - 126.
Full text (free)
19. Conceptualizing Eukaryotic Metabolic Sensing and Signaling.
Laxman S*. J Indian Institute of Science, 2017, 97(1):59-77
Full text (free)
2016
18. The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast.
Erkut C, Gade VR, Laxman S, Kurzchalia TV. eLIFE 2016 Apr 19;5. pii: e13614.
Full text (free)
Coverage: MPI-CBG news | inStem news
Covered by several mainstream newspapers
F1000 Prime Recommended
2015
17. Decoding the stem cell quiescence cycle--lessons from yeast for regenerative biology.
Dhawan J, Laxman S.* J. Cell Science. 2015; 128(24):4467-74.
Full text (free)
Publications from post-doctoral work (SL):
(2007-2014)
16. Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.
Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K.
J. Biol. Chem. 2016; 291(20):10515-27.
PDF link / Pubmed link
15. Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.
Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP. Cell Reports. 2015; 12(3):371-9.
PDF link / Pubmed link
14. Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites.
Laxman S, Sutter BM, Shi L, Tu BP. Science Signaling. 2014; 7(356):ra120.
PDF link / Pubmed link
13. Concerted effort: oscillations in global gene expression during nematode development.
Laxman S, Tu BP, McKnight SL. Mol. Cell. 2014; 53(3):363-4.
Pubmed link
12. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A.
Laxman S, Sutter BM, Tu BP. Autophagy. 2014; 10(2):386-7.
PDF link / Pubmed link
11. Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A.
Sutter BM, Wu X, Laxman S, Tu BP. Cell. 2013; 154(2):403-15.
PDF link / Pubmed link
10. Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation.
Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP. Cell. 2013; 154(2):416-29.
PDF link / Pubmed link
9. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT. PNAS. 2013; 110(24):9728-33.
Pubmed link
8. Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae.
Laxman S, Tu BP. PloS One. 2011; 6(10):e26081.
PDF link / Pubmed link
7. Systems approaches for the study of metabolic cycles in yeast.
Laxman S, Tu BP. Curr. Op. in Genetics & Development. 2010; 20(6):599-604.
PDF link / Pubmed link
6. Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters.
Laxman S, Sutter BM, Tu BP. PloS One. 2010; 5(9):e12595.
PDF link / Pubmed link
Publications from doctoral work (SL):
(2001-2006)
5. Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents.
Laxman S, Beavo JA. Molecular Interventions. 2007; 7(4):203-15.
4. Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.
Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA. PNAS. 2006; 103(50):19194-9.
3. Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi.
Díaz-Benjumea R*, Laxman S*, Hinds TR, Beavo JA, Rascón A. Biochem. Journal. 2006; 399(2):305-14.
2. Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.
Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T. Molecular and Biochemical Parasitology. 2006; 145(1):133-5.
1. Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain.
Laxman S, Rascón A, Beavo JA. J. Biol. Chem. 2005; 280(5):3771-9.