"Do. Or do not. There is no try." - Yoda
"Around here we don't look backwards for very long. We keep moving forward, opening up new doors and doing new things, because we're curious......and curiosity keeps leading us down new paths." - Walt Disney
Welcome to our lab at the Institute for Stem Cell Science and Regenerative Medicine (inStem), which shares a campus with the National Center for Biological Sciences (NCBS).
Cells are the quintessential membrane-bound units that contain the fundamental molecules of life. Yet these bags of molecules carry out remarkable chemistry to replicate their DNA, divide, grow, and change form or function. In cell groups, they communicate with each other, sharing information to control each others' fates. All of this is driven by biochemistry. We try to understand the biochemical logic driving information transfer within and between cells. At the heart of this information transfer is metabolism, which are the chemical processes required for life. Our goal is to understand what makes some metabolites special, and how they are sensed within a cell, and how they can determine what happens to a cell or groups of cells. How much of the organization of a cell can we understand by understanding the molecules that make it up?
Our research spans three areas:
(1) What makes some metabolites special, and how are they sensed/how do they signal
(2) Logic and organizational principles of metabolic regulation, and
(3) metabolic constraints that control specialization, division of labor, cooperation and conflict in cell groups.
While these address fundamental questions on cell function, our research has implications for diseases (cancer, and inter-microbial/ inter-cell interactions). Our work can also be directly applied to microbial metabolic engineering, and systems and synthetic biology.
You can learn more about our work on our research page, read our publications, join us, and explore our resources.
Our research is supported by a DBT-Wellcome Trust India Alliance fellowship, grants and institutional support from inStem, the Dept. of Biotechnology, the Dept. of Science and Technology (SERB), the EMBO global/young investigator network, and intramural support from inStem.
Other: I wrote an occasional science column for The Wire (which does not reflect the views of my employer) on the scientific method, history of science, and the process of discovery.
In addition, here are some of my other articles in the mainstream media:
1) On Scaling Indian science
2) On Effectively starting up a new lab (in the Wellcome Trust -DBT IA newsletter)
3) "Who moved my science", a science policy discussion on the Pragati podcast
office phone: +91-80-23666580
Snail mail/physical address:
Institute for Stem Cell Biology and Regenerative Medicine (inStem)
National Center for Biological Sciences campus,
GKVK, Bellary Road,
Bangalore 560065 India
Institute (official/other) website: